Reading striker Nick Blackman will miss the season opener with Ipswich as he serves a one-match ban for an altercation with a steward last year.
Royston Drenthe, Wayne Bridge and Danny Williams, who have played international football for Netherlands, England and the US respectively could make debuts.
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Ipswich's revamped squad has 10 new players including keeper Dean Gerken and ex-Reading midfielder Jay Tabb.
Defenders Christophe Berra and Frederic Veseli are also in contention.
MATCH FACTS
Head-to-head
• Reading are chasing a fifth successive victory over Ipswich.
• The Tractor Boys have scored 36 goals and conceded 35 in league matches on Reading turf in their history, and have only managed two clean sheets in the process.
• This is the 49th league clash and 149 goals have featured in the previous 48.
Reading
• Reading return to the Championship after a single season stay in the highest echelon, and are aiming to achieve a third promotion to the Premier League.
• Nigel Adkins's side are kicking off a new campaign at home for the fifth season in a row, but have not won at the Madejski Stadium since early February, and will be anxious to avoid the 400th home league defeat in their history.
• The Royals have drawn five of their last six opening league fixtures, and last won one in 2006.
Ipswich Town
• Ipswich are entering a 12th consecutive season of second-tier football; the longest current residency in the Championship.
• The 1-0 Premier League defeat by Sunderland in 2001 was the last time Ipswich failed to score on the opening day of a league season. They're chasing a third winning start in four years.
• Mick McCarthy, who guided the Tractor Boys from bottom of the table in November to a 14th placed finish, is starting his first full season at Portman Road.