Watch Man Utd V Shakhtar Donetsk Live Stream UEFA Champions League Match 10 -December 2013. Defenders Nemanja Vidic, Patrice Evra and Chris Smalling are doubts for Manchester United's Champions League tie against Shakhtar Donetsk.
The trio, as well as Marouane Fellaini, missed training on Monday.
The midfielder has been troubled with a back problem and is doubtful but Shinji Kagawa could be available after missing the loss to Newcastle through illness.
United have qualified for the knockout stages but need a point on Tuesday to secure top spot in their group.
Even though victory is not essential for United's European hopes, manager David Moyes will be hoping for a win over the Ukrainian team after a torrid week.
CONTRASTING LEAGUE FORM
United have only won five of their last 12 league games at Old Trafford, scoring just eight goals in eight home league games
Shakhtar are five points clear at the top of their league going into the winter break. Their next league game will be on 1 March.
Recent defeats by Everton and Newcastle in the Premier League saw the reigning champions suffer back-to-back home losses for the first time since 2002.
And victory for Shakhtar at Old Trafford, which would be their first in England, would ensure Mircea Lucescu's team would overtake United at the top of Group A.
In response to whether he would rest players for the tie, Moyes said: "There's a little bit of that in my thinking but we've also got one or two injuries that I'll need to look after and that comes into my consideration."
Should Moyes opt for his strongest line-up Wayne Rooney and Robin van Persie could spearhead United's attack for the first time in a month.
Rooney, 28, is available after missing Saturday's match against Newcastle through suspension.
"With a player of Wayne's calibre we can go from strength to strength and become even better than we are now," Van Persie, who returned from injury against Newcastle, told MUTV.
"It is important that this partnership is growing and becoming even stronger."