Watch Man Utd V Newcastle Live Stream Barclays Premier League Match 7 -December 2013. Manchester United forward Wayne Rooney is suspended after being booked for the fifth time this season in Wednesday's defeat by Everton.
Phil Jones is available after a ban, but Shinji Kagawa and Robin van Persie are doubts because of respective illness and injury.
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Newcastle forward Papiss Cisse faces a fitness test on the heel injury which ruled him out of the defeat by Swansea.
Hatem Ben Arfa also missed that game with illness but should be fit.
MATCH PREVIEW
Until Wednesday, Everton hadn't won away to Manchester United since 1992 - so even without the David Moyes against his old club scenario, it was a pretty big deal.
Let's face it - every United home defeat is, and we COULD be dealing with something even bigger this time.
Newcastle haven't beaten United at Old Trafford since 1972, when goals from John Tudor and Stewart Barrowclough gave the Magpies their one and only success since 1950. That's one win in 48 games spanning 63 years.
Over those years they've generally had a good go in vain, with last season's Premier League visit a prime example. Three times Newcastle led, only to be beaten 4-3. They'll just have to take the lead once this time to make the home regulars restless.
They've seen their side drop 10 points at home already this season - one more than went begging in the whole of last term - and whilst nobody could credibly suggest that United are experiencing a clichéd 'crisis', they can ill-afford to drop many more if they're to challenge for a top four place, let alone the title.
The last time they had as few points after 14 games was in 2001-02 when they went on to finish third.
Currently as close to the bottom three as they are to Arsenal at the top, Moyes might even take third if offered it now, having admitted that his side "will have to play some great football and win an awful lot of games in the run-in".
After four successive wins, Newcastle suffered their own setback at Swansea on Wednesday, but that won't stop Alan Pardew from thinking - like many other managers - that this is the season to go to Old Trafford undaunted.
Teams have a prayer there now, with Manchester United fans perhaps offering a few up to the 'man upstairs'. That's Sir Alex Ferguson, for the avoidance of doubt.
MATCH FACTS
Head-to-head
Newcastle have only won one of their last 23 matches against Manchester United in all competitions - a 3-0 Premier League home victory in January 2012.
In total, they have only won four of their 38 Premier League matches against the Red Devils - all at St James' Park.
Manchester United have won 78 Premier League points against Newcastle - more than any other club has against the Geordies.
In last season's encounter on Boxing Day at Old Trafford, the home side came from behind three times to win 4-3 thanks to a last-minute goal from Javier Hernandez.
Manchester United
The Red Devils have now failed to score in two Premier League home games in the same season for the first time since 2006-07.
They have only won five of their last 11 league games at Old Trafford.
United have conceded more goals than any other club in the top half of the table - bar Newcastle.
If Robin van Persie does not recover from injury this will be the first time United have played a league game without either him or Wayne Rooney in their side since the Dutchman arrived.
United have scored only eight goals in seven Premier League home games this season, fewer than bottom of the league Sunderland.
They have not lost successive Premier League home games since May 2002.
Newcastle United
Newcastle have alternated between wins and defeats in their last eight away games in the league.
Their defeat at Swansea brought to an end their run of four straight wins and it was only their second defeat in their last eight matches.
They have conceded 14 goals away from home in the league this season - a total only surpassed by three other teams.